A genetic and developmental biological approach for a family with complex congenital heart diseases—evidence of digenic inheritance

A genetic and developmental biological approach for a family with complex congenital heart diseases—evidence of digenic inheritance

ObjectiveCongenital heart disease (CHD) is caused by cardiovascular developmental defects and has a global prevalence of ∼1%. The etiology of CHD is multifactorial and remains generally unknown, despite advances in analytical techniques based on next-generation sequencing (NGS). The aim of our study...

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Bibliographic Details
Main Authors: Yu Yoshida, Keiko Uchida, Kazuki Kodo, Reina Ishizaki-Asami, Jun Maeda, Yoshinori Katsumata, Shinsuke Yuasa, Keiichi Fukuda, Kenjiro Kosaki, Yusuke Watanabe, Osamu Nakagawa, Hiroyuki Yamagishi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
trio gene analysis
nodal
tbx20
complex congenital heart disease
rare variants
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2023.1135141/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2023.1135141/full

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