NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats

NLRP3 downregulation enhances engraftment and functionality of adipose-derived stem cells to alleviate erectile dysfunction in diabetic rats

BackgroundThe transplantation of adipose-derived stem cells (ASCs) is a most promising treatment for diabetic erectile dysfunction (DMED). However, the effect of high glucose on the post-transplantation survival of stem cells limits the efficacy of ASCs transplantation. Prolonging the survival time...

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Bibliographic Details
Main Authors: Chao Luo, Yaqian Peng, Xiongcai Zhou, Junhong Fan, Weihong Chen, Haibo Zhang, Anyang Wei
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-07-01
Series:Frontiers in Endocrinology
Subjects:
adipose derived stem cell
erectile dysfunction
pyroptosis
gene modification
diabetes mellitus
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2022.913296/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.913296/full

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