In silico profiling of non-synonymous SNPs in IDS gene for early diagnosis of Hunter syndrome

Abstract Background Single amino acid substitutions in the Iduronate-2-sulfatase enzyme result in destabilization of the protein and cause a genetic disorder called Hunter syndrome. To gain functional insight into the mutations causing Hunter syndrome, various bioinformatics tools were employed, and...

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Main Authors: Adarshan Sivakumar, Yuvaraj Dinakarkumar, Wahidah H. Al-Qahtani, Muthusamy Karnan, Jothiramalingam Rajabathar, Arokiyaraj Charumathi, Elakiya Sadhaasivam, Aparna Preetha Venugopal, Baljeet Mukhtiar Singh, Maqbool Qutub, Sai Ramesh Anjaneyulu
Format: Article
Language:English
Published: SpringerOpen 2022-03-01
Series:Egyptian Journal of Medical Human Genetics
Subjects:
Online Access:https://doi.org/10.1186/s43042-022-00271-3