Differential gradients of immunotherapy vs targeted therapy efficacy according to the sun-exposure pattern of the site of occurrence of primary melanoma: a multicenter prospective cohort study (MelBase)

Differential gradients of immunotherapy vs targeted therapy efficacy according to the sun-exposure pattern of the site of occurrence of primary melanoma: a multicenter prospective cohort study (MelBase)

BackgroundThe tumor mutational burden (TMB) is high in melanomas owing to UV-induced oncogenesis. While a high TMB is a predictive biomarker of response to PD-1 inhibitors, it may be associated with the rise of resistant clones to targeted therapy over time. We hypothesized that survivals may depend...

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Bibliographic Details
Main Authors: David Russo, Stéphane Dalle, Olivier Dereure, Laurent Mortier, Sophie Dalac-Rat, Caroline Dutriaux, Marie-Thérèse Leccia, Delphine Legoupil, Henri Montaudié, Eve Maubec, Julie De Quatrebarbes, Jean-Philippe Arnault, Florence Granel Brocard, Philippe Saïag, Brigitte Dreno, Clara Allayous, Bastien Oriano, Wendy Lefevre, Céleste Lebbé, Lise Boussemart
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Oncology
Subjects:
melanoma
immunotherapy
sun-exposure
acral melanoma
UV signature
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1250026/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2023.1250026/full

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