Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors

Molecular Modelling Study and Antibacterial Evaluation of Diphenylmethane Derivatives as Potential FabI Inhibitors

The need for new antibiotics has become a major worldwide challenge as bacterial strains keep developing resistance to the existing drugs at an alarming rate. Enoyl-acyl carrier protein reductases (FabI) play a crucial role in lipids and fatty acid biosynthesis, which are essential for the integrity...

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Bibliographic Details
Main Authors: Shaima Hasan, Kawthar Kayed, Rose Ghemrawi, Nezar Al Bataineh, Radwa E. Mahgoub, Rola Audeh, Raghad Aldulaymi, Noor Atatreh, Mohammad A. Ghattas
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Molecules
Subjects:
enoyl-acyl carrier protein transferase
FabI
diphenyl methane
triclosan
lead optimization
docking
Online Access:https://www.mdpi.com/1420-3049/28/7/3000

Internet

https://www.mdpi.com/1420-3049/28/7/3000

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