Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors

Structure Activity Relationship and Molecular Docking of Some Quinazolines Bearing Sulfamerazine Moiety as New 3CLpro, cPLA2, sPLA2 Inhibitors

The current work was conducted to synthesize several novel anti-inflammatory quinazolines having sulfamerazine moieties as new 3CLpro, cPLA2, and sPLA2 inhibitors. The thioureido derivative <b>3</b> was formed when compound <b>2</b> was treated with sulfamerazine. Also, compo...

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Bibliographic Details
Main Authors: Mohammed Abdalla Hussein, Rita M. Borik, Mohamed S. Nafie, Heba M. Abo-Salem, Sylvia A. Boshra, Zahraa N. Mohamed
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molecules
Subjects:
quinazolines
sulfamerazine
3CLpro
cPLA2
sPLA2
IL-8
Online Access:https://www.mdpi.com/1420-3049/28/16/6052

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