Design, synthesis, and anticancer activity of three novel palbociclib derivatives

Design, synthesis, and anticancer activity of three novel palbociclib derivatives

Cancer is one of the most serious diseases threatening human health, so it is particularly important to develop effective tumor-targeting drugs. As the first CDK4/6 inhibitor, palbociclib effectively inhibits tumor proliferation by blocking the cell cycle to the G1 phase. 10-HCPT is a Topo I inhibit...

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Bibliographic Details
Main Authors: Tian Li, An-Di Zhou, Li-Fei Bai, Xiao-Yang Zhang, Yu-Ting Zhou, Hai-Li Yang, Le-Tian Xu, Xin-Qin Guo, Xi-Yu Zhu, Dong-Jin Wang, Hong-Wei Gu, Xiao-Ming Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Oncology
Subjects:
palbociclib derivatives
anticancer activity
CDK4/6
10-hydroxy camptothecin
Topo I
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.959322/full

Internet

https://www.frontiersin.org/articles/10.3389/fonc.2022.959322/full

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