Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson’s disease

Abstract Background Epidemiological studies suggest a link between the melanoma-related pigmentation gene melanocortin 1 receptor (MC1R) and risk of Parkinson’s disease (PD). We previously showed that MC1R signaling can facilitate nigrostriatal dopaminergic neuron survival. The present study investi...

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Bibliographic Details
Main Authors: Waijiao Cai, Pranay Srivastava, Danielle Feng, Yue Lin, Charles R. Vanderburg, Yuehang Xu, Pamela Mclean, Matthew P. Frosch, David E. Fisher, Michael A. Schwarzschild, Xiqun Chen
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Molecular Neurodegeneration
Subjects:
Melanocortin 1 receptor
Alpha-synuclein
Parkinson’s disease
Melanoma
Nuclear factor erythroid 2-related factor 2
Online Access:https://doi.org/10.1186/s13024-022-00520-4

Internet

https://doi.org/10.1186/s13024-022-00520-4

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