Assessment of stromal SCD-induced drug resistance of PDAC using 3D-printed zPDX model chips

Assessment of stromal SCD-induced drug resistance of PDAC using 3D-printed zPDX model chips

Summary: Lipid metabolism is extensively reprogrammed in pancreatic ductal adenocarcinoma (PDAC). Stearoyl-coenzyme A desaturase (SCD) is a critical lipid regulator that was unexplored in PDAC. Here, we characterized the existence of cancer-associated fibroblasts (CAFs) with high SCD expression, and...

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Bibliographic Details
Main Authors: Chuntao Wu, Beiyuan Hu, Lei Wang, Xia Wu, Haitao Gu, Hanguang Dong, Jiuliang Yan, Zihao Qi, Qi Zhang, Huan Chen, Bo Yu, Sheng Hu, Yu Qian, Shuang Dong, Qiang Li, Xu Wang, Jiang Long
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:iScience
Subjects:
Cancer
Lipid
Microenvironment
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222019964

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http://www.sciencedirect.com/science/article/pii/S2589004222019964

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