Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin

Oxidized low density lipoprotein in the liver causes decreased permeability of liver lymphatic- but not liver sinusoidal-endothelial cells via VEGFR-3 regulation of VE-Cadherin

The lymphatic vasculature of the liver is vital for liver function as it maintains fluid and protein homeostasis and is important for immune cell transport to the lymph node. Chronic liver disease is associated with increased expression of inflammatory mediators including oxidized low-density lipopr...

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Bibliographic Details
Main Authors: Alyssa R. Goldberg, Megan Ferguson, Sarit Pal, Rachel Cohen, David J. Orlicky, Rebecca L. McCullough, Joseph M. Rutkowski, Matthew A. Burchill, Beth A. Jirón Tamburini
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-10-01
Series:Frontiers in Physiology
Subjects:
lymphatic endothelial cell
liver sinusoidal endothelial cell
alcohol-associated liver disease
cholestasis
non-alcoholic fatty liver disease
VE-cadherin
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.1021038/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2022.1021038/full

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