3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors

3-Arylidene-2-oxindoles as Potent NRH:Quinone Oxidoreductase 2 Inhibitors

The enzyme NRH:quinone oxidoreductase 2 (NQO2) plays an important role in the pathogenesis of various diseases such as neurodegenerative disorders, malaria, glaucoma, COVID-19 and cancer. NQO2 expression is known to be increased in some cancer cell lines. Since 3-arylidene-2-oxindoles are widely use...

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Bibliographic Details
Main Authors: Natalia A. Lozinskaya, Elena N. Bezsonova, Meriam Dubar, Daria D. Melekhina, Daniil R. Bazanov, Alexander S. Bunev, Olga B. Grigor’eva, Vladlen G. Klochkov, Elena V. Sokolova, Denis A. Babkov, Alexander A. Spasov, Sergey E. Sosonyuk
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Molecules
Subjects:
oxindoles
indolin-2-ones
NQO2
NRH:quinone oxidoreductase 2
3-arylidene-2-oxindoles
anticancer
Online Access:https://www.mdpi.com/1420-3049/28/3/1174

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https://www.mdpi.com/1420-3049/28/3/1174

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