The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism

The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism

Objectives: This study aimed to evaluate if the protective effect of Isoliquiritigenin (ISL) against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling. Methods: Adult male Wistart rats were treated as control, ISL, DOX, DOX, and ISL + DOX + ISL + Nrf2 inhibitor (brusatol)...

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Bibliographic Details
Main Authors: Wahidah H. Al-Qahtani, Ghedeir M. Alshammari, Mohammad A. Alshuniaber, Mureed Husain, Sarah A. Alawwad, Salwa T. Al-Ayesh, Mohammed Abdo Yahya, Abdulrahman S. Aldawood
Format: Article
Language:English
Published: Elsevier 2022-08-01
Series:Journal of King Saud University: Science
Subjects:
Isoliquiritigenin
Doxorubicin
Nrf2
Antioxidant
Kidney
Online Access:http://www.sciencedirect.com/science/article/pii/S1018364722003469

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http://www.sciencedirect.com/science/article/pii/S1018364722003469

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