The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism

The protective effect of isoliquiritigenin against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling as one key mechanism

Objectives: This study aimed to evaluate if the protective effect of Isoliquiritigenin (ISL) against doxorubicin-induced nephropathy in rats entails activation of Nrf2 signaling. Methods: Adult male Wistart rats were treated as control, ISL, DOX, DOX, and ISL + DOX + ISL + Nrf2 inhibitor (brusatol)...

Full description

Bibliographic Details
Main Authors:	Wahidah H. Al-Qahtani, Ghedeir M. Alshammari, Mohammad A. Alshuniaber, Mureed Husain, Sarah A. Alawwad, Salwa T. Al-Ayesh, Mohammed Abdo Yahya, Abdulrahman S. Aldawood
Format:	Article
Language:	English
Published:	Elsevier 2022-08-01
Series:	Journal of King Saud University: Science
Subjects:	Isoliquiritigenin Doxorubicin Nrf2 Antioxidant Kidney
Online Access:	http://www.sciencedirect.com/science/article/pii/S1018364722003469

Similar Items

Isoliquiritigenin attenuates neuroinflammation in mice model of Parkinson’s disease by promoting Nrf2/NQO-1 pathway
by: Huang Lijuan, et al.
Published: (2022-09-01)

The licorice dietary component isoliquiritigenin chemosensitizes human uterine sarcoma cells to doxorubicin and inhibits cell growth by inducing apoptosis and autophagy via inhibition of m-TOR signaling
by: Li-Chun Lin, et al.
Published: (2017-06-01)

Isoliquiritigenin inhibits apoptosis and ameliorates oxidative stress in rheumatoid arthritis chondrocytes through the Nrf2/HO-1-mediated pathway
by: Shih-Ya Hung, et al.
Published: (2024-01-01)

Isoliquiritigenin Ameliorates Ischemia-Induced Myocardial Injury via Modulating the Nrf2/HO-1 Pathway in Mice
by: Yao D, et al.
Published: (2022-04-01)

Perspectives on the Role of Isoliquiritigenin in Cancer
by: Kai-Lee Wang, et al.
Published: (2021-01-01)

Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling
by: Man Zhang, et al.
Published: (2018-08-01)

Corrigendum: Isoliquiritigenin Protects Against Pancreatic Injury and Intestinal Dysfunction After Severe Acute Pancreatitis via Nrf2 Signaling
by: Man Zhang, et al.
Published: (2019-07-01)

Kaempferol attenuates doxorubicin-mediated nephropathy in rats by activating SIRT1 signaling
by: Reham I. Alagal, et al.
Published: (2022-02-01)

Protective effect of isoliquiritigenin in amiodarone‐induced damage of human umbilical vein endothelial cells
by: Jin‐Li Guo, et al.
Published: (2023-11-01)

Isoliquiritigenin Attenuates Atherogenesis in Apolipoprotein E-Deficient Mice
by: Fen Du, et al.
Published: (2016-11-01)

Isoliquiritigenin Inhibits Ovarian Cancer Metastasis by Reversing Epithelial-to-Mesenchymal Transition
by: Chen Chen, et al.
Published: (2019-10-01)

Isoliquiritigenin attenuates high-fat diet-induced intestinal damage by suppressing inflammation and oxidative stress and through activating Nrf2
by: Mohammed Abdo Yahya, et al.
Published: (2022-05-01)

Isoliquiritigenin Derivatives Inhibit RANKL-Induced Osteoclastogenesis by Regulating p38 and NF-κB Activation in RAW 264.7 Cells
by: Seongtae Jeong, et al.
Published: (2020-08-01)

Protective effect of cafestol against doxorubicin-induced cardiotoxicity in rats by activating the Nrf2 pathway
by: Sara A. Al-Kenany, et al.
Published: (2023-06-01)

Effect of particle size on the oral absorption of isoliquiritigenin nanocrystals
by: Yanni Ma, et al.
Published: (2023-01-01)

Isoliquiritigenin Attenuates UUO-Induced Renal Inflammation and Fibrosis by Inhibiting Mincle/Syk/NF-Kappa B Signaling Pathway
by: Liao Y, et al.
Published: (2020-04-01)

Isoliquiritigenin Nanoemulsion Preparation by Combined Sonication and Phase-Inversion Composition Method: In Vitro Anticancer Activities
by: Jianman Wang, et al.
Published: (2022-08-01)

Phytochemical and Pharmacological Role of Liquiritigenin and Isoliquiritigenin From Radix Glycyrrhizae in Human Health and Disease Models
by: Mahesh Ramalingam, et al.
Published: (2018-11-01)

Concomitant Sub-Chronic Administration of Small-Size Gold Nanoparticles Aggravates Doxorubicin-Induced Liver Oxidative and Inflammatory Damage, Hyperlipidemia, and Hepatic Steatosis
by: Ghedeir M. Alshammari, et al.
Published: (2023-01-01)

Modulation of Nrf2 by quercetin in doxorubicin-treated rats
by: Anish Sharma, et al.
Published: (2020-04-01)

The inhibitory effect of Isoliquiritigenin on the proliferation of human arterial smooth muscle cell
by: Tianbao Chen, et al.
Published: (2017-07-01)

Isoliquiritigenin attenuates lipopolysaccharide-induced cognitive impairment through antioxidant and anti-inflammatory activity
by: Xiaobo Zhu, et al.
Published: (2019-08-01)

Preparation and in vitro and in vivo evaluation of an isoliquiritigenin-loaded ophthalmic nanoemulsion for the treatment of corneal neovascularization
by: Rui Zhang, et al.
Published: (2022-12-01)

Colon-specific delivery of isoliquiritigenin by oral edible zein/caseate nanocomplex for ulcerative colitis treatment
by: Meng Xiao, et al.
Published: (2022-09-01)

Deep learning-assisted high-content screening identifies isoliquiritigenin as an inhibitor of DNA double-strand breaks for preventing doxorubicin-induced cardiotoxicity
by: Xuechun Chen, et al.
Published: (2023-10-01)

Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling
by: Yue Fu, et al.
Published: (2021-02-01)

Isoliquiritigenin Suppresses E2-Induced Uterine Leiomyoma Growth through the Modulation of Cell Death Program and the Repression of ECM Accumulation
by: Po-Han Lin, et al.
Published: (2019-08-01)

Therapeutic Intervention in Cancer by Isoliquiritigenin from Licorice: A Natural Antioxidant and Redox Regulator
by: Zhu Zhang, et al.
Published: (2022-07-01)

Isoliquiritigenin Enhances the Beige Adipocyte Potential of Adipose-Derived Stem Cells by JNK Inhibition
by: Hanbyeol Moon, et al.
Published: (2020-12-01)

Isoliquiritigenin Alleviates Semen Strychni-Induced Neurotoxicity by Restoring the Metabolic Pathway of Neurotransmitters in Rats
by: Lu Wang, et al.
Published: (2021-11-01)

Mechanisms of Triptolide-Induced Hepatotoxicity and Protective Effect of Combined Use of Isoliquiritigenin: Possible Roles of Nrf2 and Hepatic Transporters
by: Zhenyan Hou, et al.
Published: (2018-03-01)

Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway
by: Xiaoliang Hu, et al.
Published: (2022-04-01)

The effects and mechanisms of isoliquiritigenin loaded nanoliposomes regulated AMPK/mTOR mediated glycolysis in colorectal cancer
by: Gang Wang, et al.
Published: (2020-01-01)

Anti-inflammation of isoliquiritigenin via the inhibition of NF-κB and MAPK in LPS-stimulated MAC-T cells
by: Manman Li, et al.
Published: (2022-08-01)

Inclusion Complex of Isoliquiritigenin With Sulfobutyl Ether-β-Cyclodextrin: Preparation, Characterization, Inclusion Mode, Solubilization, and Stability
by: Xiaozheng Wu, et al.
Published: (2022-06-01)

Isoliquiritigenin suppresses human melanoma growth by targeting miR-301b/LRIG1 signaling
by: Shijian Xiang, et al.
Published: (2018-08-01)

Melatonin alleviates doxorubicin-induced cardiotoxicity via inhibiting oxidative stress, pyroptosis and apoptosis by activating Sirt1/Nrf2 pathway
by: Wei Zhang, et al.
Published: (2023-06-01)

Network analysis and experimental pharmacology study explore the protective effects of Isoliquiritigenin on 5-fluorouracil-Induced intestinal mucositis
by: Yi-fan Liao, et al.
Published: (2022-10-01)

Long-Circulation and Brain Targeted Isoliquiritigenin Micelle Nanoparticles: Formation, Characterization, Tissue Distribution, Pharmacokinetics and Effects for  Ischemic Stroke
by: Song W, et al.
Published: (2022-08-01)

Co-Treatment With Resveratrol and FGF1 Protects Against Acute Liver Toxicity After Doxorubicin Treatment via the AMPK/NRF2 Pathway
by: Xianchou Xu, et al.
Published: (2022-08-01)