IRE1α‐XBP1s axis regulates SREBP1‐dependent MRP1 expression to promote chemoresistance in non‐small cell lung cancer cells

IRE1α‐XBP1s axis regulates SREBP1‐dependent MRP1 expression to promote chemoresistance in non‐small cell lung cancer cells

Abstract Background Inositol‐requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)‐resident transmembrane protein that senses ER stress and mediates an essential arm of the unfolded protein response (UPR). IRE1 reduces ER stress by upregulating the expression of multiple ER chaperones through a...

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Bibliographic Details
Main Authors: Yuzhou Xu, Feng Gui, Zhe Zhang, Zhongyang Chen, Tiange Zhang, Yunhan Hu, Huijun Wei, Yuchen Fu, Xinde Chen, Zhihao Wu
Format: Article
Language:English
Published: Wiley 2024-10-01
Series:Thoracic Cancer
Subjects:
chemoresistance
IRE1α
MRP1
SREBP1
XBP1
Online Access:https://doi.org/10.1111/1759-7714.15442

Internet

https://doi.org/10.1111/1759-7714.15442

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