A Novel Cardenolide Glycoside Isolated from <i>Xysmalobium undulatum</i> Reduces Levels of the Alzheimer’s Disease-Associated β-Amyloid Peptides Aβ42 In Vitro

A Novel Cardenolide Glycoside Isolated from <i>Xysmalobium undulatum</i> Reduces Levels of the Alzheimer’s Disease-Associated β-Amyloid Peptides Aβ42 In Vitro

Elevated levels of the amylo β-proteins (Aβ), particularly Aβ42, are associated with a high risk of Alzheimer’s disease (AD). The Aβ proteins are produced from cellular processing of the amyloid precursor proteins (APPs). To identify natural products that block the formation of Aβ-proteins from APPs...

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Bibliographic Details
Main Authors: Anuradha Thakur, Phanankosi Moyo, Carl Johan van der Westhuizen, Hyun Ok Yang, Vinesh Maharaj
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceuticals
Subjects:
<i>Xysmalobium undulatum</i>
Aβ42 reduction
nuclear magnetic resonance (NMR)
acetylated glycosydated crotoxigenin
xysmalogenin-3
β-<span style="font-variant: small-caps">d</span>-glucopyranoside
Online Access:https://www.mdpi.com/1424-8247/14/8/743

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https://www.mdpi.com/1424-8247/14/8/743

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