Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the axon. TAU is missorted and aggregated in an array of diseases known as tauopathies. Microtubules are essential for neuronal function and regulated via a complex set of post-translational modifications, ch...

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Bibliographic Details
Main Authors: Mohamed Aghyad Al Kabbani, Christoph Köhler, Hans Zempel
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2025-08-01
Series:Neural Regeneration Research
Subjects:
human induced pluripotent stem cell
microtubules
p301l
pr5 mice
tau
tauopathy
tubulin code
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-23-01742

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https://journals.lww.com/10.4103/NRR.NRR-D-23-01742

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