Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells

Reactivation of hyperglycemia-induced hypocretin (HCRT) gene silencing by N-acetyl-d-mannosamine in the orexin neurons derived from human iPS cells

Orexin neurons regulate critical brain activities for controlling sleep, eating, emotions, and metabolism, and impaired orexin neuron function results in several neurologic disorders. Therefore, restoring normal orexin function and understanding the mechanisms of loss or impairment of orexin neurons...

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Bibliographic Details
Main Authors: Koji Hayakawa, Yasuharu Sakamoto, Osamu Kanie, Atsuko Ohtake, Shusaku Daikoku, Yukishige Ito, Kunio Shiota
Format: Article
Language:English
Published: Taylor & Francis Group 2017-09-01
Series:Epigenetics
Subjects:
histone acetylation
hyperglycemia
neurodegeneration
orexin
o-glcnacylation
Online Access:http://dx.doi.org/10.1080/15592294.2017.1346775

Internet

http://dx.doi.org/10.1080/15592294.2017.1346775

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