A modified mouse model of haemorrhagic transformation associated with tPA administration after thromboembolic stroke

Objective: To establish a new mouse model of haemorrhagic transformation associated with delayed tissue-type plasminogen activator (tPA) treatment to provide a novel tool to study therapeutic strategies for haemorrhagic transformation. Methods: Male C57BL/6 mice were subjected to carotid artery thro...

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Bibliographic Details
Main Authors: Yang Ye, Xi-Yan Xin, Hao-Lin Zhang, Rui-Wen Fan, Yu-Tian Zhu, Dong Li
Format: Article
Language:English
Published: Elsevier 2023-01-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023003092