MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinoma

MLH1 mediates cytoprotective nucleophagy to resist 5-Fluorouracil-induced cell death in colorectal carcinoma

Colorectal Cancer (CRC) with Microsatellite instability (MSI) and mutLhomolog-1 (MLH1) gene deficiency are less aggressive than MLH1 proficient cancers. MLH1 is involved in several cellular processes, but its connection with the autophagy-dependent cellular response towards anticancer drugs remains...

Full description

Bibliographic Details
Main Authors: Shaista Manzoor, Maha Saber-Ayad, Azzam A. Maghazachi, Qutayba Hamid, Jibran Sualeh Muhammad
Format: Article
Language:English
Published: Elsevier 2022-02-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Colorectal cancer
Microsatellite instability
Autophagy
Nucleophagy
Chemoresistance
CRISPR-Cas9
Online Access:http://www.sciencedirect.com/science/article/pii/S147655862100107X

Internet

http://www.sciencedirect.com/science/article/pii/S147655862100107X

Similar Items