CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment

CXCR4-guided liposomes regulating hypoxic and immunosuppressive microenvironment for sorafenib-resistant tumor treatment

Clinical sorafenib treatment could activate C-X-C receptor type 4 (CXCR4)/stromal source factor-1α (SDF-1α) axis to aggravate intra-tumoral hypoxia of hepatocellular carcinoma (HCC), which further leads to progression, invasion, metastasis, and immunosuppression of tumors and in return causes resist...

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Bibliographic Details
Main Authors: Yuehua Wang, Zhenjie Wang, Fei Jia, Qing Xu, Zhilin Shu, Junlin Deng, Aimin Li, Meng Yu, Zhiqiang Yu
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-11-01
Series:Bioactive Materials
Subjects:
Hepatocellular carcinoma
Sorafenib resistance
Hypoxia relief
Immunotherapy
Tumor targeting regulation
Online Access:http://www.sciencedirect.com/science/article/pii/S2452199X22000032

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http://www.sciencedirect.com/science/article/pii/S2452199X22000032

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