Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation

Glycolysis mediates neuron specific histone acetylation in valproic acid-induced human excitatory neuron differentiation

Pregnancy exposure of valproic acid (VPA) is widely adopted as a model of environmental factor induced autism spectrum disorder (ASD). Increase of excitatory/inhibitory synaptic transmission ratio has been proposed as the mechanism of VPA induced ASD. How this happened, particularly at the level of...

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Bibliographic Details
Main Authors: Andi Chen, Mengmeng Wang, Chao Xu, Youyi Zhao, Panpan Xian, Yuqian Li, Weian Zheng, Xuyang Yi, Shengxi Wu, Yazhou Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-04-01
Series:Frontiers in Molecular Neuroscience
Subjects:
valproic acid
human embryonic stem cells
differentiation
glycolysis
histone acetylation
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2023.1151162/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2023.1151162/full

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