α2-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling

α2-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling

Adrenergic signaling is a well-known input into pancreatic islet function. Specifically, the insulin-secreting islet β cell expresses the Gi/o-linked α2-adrenergic receptor, which upon activation suppresses insulin secretion. The use of the adrenergic agonist epinephrine at micromolar doses may have...

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Bibliographic Details
Main Authors: Michael A. Kalwat, Zhimin Huang, Derk D. Binns, Kathleen McGlynn, Melanie H. Cobb
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
cell signaling
pancreatic islet
extracellular-signal-regulated kinase
brain-derived neurotrophic factor
BDNF/NT-3 growth factors receptor
epinephrine
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.576396/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.576396/full

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