Universal CARs, universal T cells, and universal CAR T cells

Abstract Currently, the two approved T cell products with chimeric antigen receptors (CAR) are from autologous T cells. These CAR T cells approved for clinical use must be generated on a custom-made basis. This case-by-case autologous T cell production platform remains a significant limiting factor...

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Bibliographic Details
Main Authors: Juanjuan Zhao, Quande Lin, Yongping Song, Delong Liu
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Hematology & Oncology
Online Access:http://link.springer.com/article/10.1186/s13045-018-0677-2