Chemical zymogens for the protein cysteinome

Chemical zymogens for the protein cysteinome

Reversible on/off switches for enzyme activity are foundational in nature but are challenging to design using tools of synthetic chemistry. Here the authors design chemical zymogens amenable for activation via biomolecular interactions.

Bibliographic Details
Main Authors: Mireia Casanovas Montasell, Pere Monge, Sheiliza Carmali, Livia Mesquita Dias Loiola, Dante Guldbrandsen Andersen, Kaja Borup Løvschall, Ane Bretschneider Søgaard, Maria Merrild Kristensen, Jean Maurice Pütz, Alexander N. Zelikin
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32609-1

Internet

https://doi.org/10.1038/s41467-022-32609-1

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