Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus

Long-term Surgical and Chemical Castration Deteriorates Memory Function Through Downregulation of PKA/CREB/BDNF and c-Raf/MEK/ERK Pathways in Hippocampus

Purpose Goserelin is a drug used for chemical castration. In a rat model, we investigated whether surgical and chemical castration affected memory ability through the protein kinase A (PKA)/cyclic adenosine monophosphate response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF...

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Bibliographic Details
Main Authors: Mal-Soon Shin, Tae-Won Kim, Sang-Seo Park, Il-Gyu Ko, Chang-Ju Kim, Mia Kim, Su Yeon Roh, Kwang Taek Kim, Khae Hawn Kim
Format: Article
Language:English
Published: Korean Continence Society 2019-06-01
Series:International Neurourology Journal
Subjects:
Castration
Memory
Neurogenesis
Online Access:http://www.einj.org/upload/pdf/inj-1938103-052.pdf

Internet

http://www.einj.org/upload/pdf/inj-1938103-052.pdf

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