Low- and high-cocaine intake affects the spatial and temporal dynamics of class IIa HDAC expression-activity in the nucleus accumbens and hippocampus of male rats as measured by [18F]TFAHA PET/CT neuroimaging

Low- and high-cocaine intake affects the spatial and temporal dynamics of class IIa HDAC expression-activity in the nucleus accumbens and hippocampus of male rats as measured by [18F]TFAHA PET/CT neuroimaging

Repeated cocaine alters neuronal function in the nucleus accumbens (NAc), a brain region involved in cocaine taking, and in hippocampus (HC), known for contextual and associative learning. [18F]TFAHA is a histone deacetylase (HDAC) class IIa-specific radiotracer for positron emission tomography (PET...

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Bibliographic Details
Main Authors: Shane A. Perrine, Walid F. Alsharif, Arman Harutyunyan, Swatabdi Kamal, Nerissa T. Viola, Juri G. Gelovani
Format: Article
Language:English
Published: Elsevier 2022-12-01
Series:Addiction Neuroscience
Subjects:
Cocaine
Rat
Epigenetics
Histone deacetylase
Positron emission tomography
Online Access:http://www.sciencedirect.com/science/article/pii/S2772392522000414

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http://www.sciencedirect.com/science/article/pii/S2772392522000414

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