Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway

Guilu Erxian glue reduces endoplasmic reticulum stress-mediated apoptosis and restores the balance of extracellular matrix synthesis and degradation in chondrocytes by inhibiting the ATF6/GRP78/CHOP signaling pathway

Knee Osteoarthritis (KOA) is characterized by phenotypic alterations, apoptosis, and the breakdown of the extracellular matrix (ECM) in the superficial articular cartilage cells. The inflammatory response activates the Endoplasmic Reticulum Stress (ERS) signaling pathway, which plays a critical role...

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Bibliographic Details
Main Authors: Qiudong Geng, Weixin Wu, Meixin Yang, Fucheng Gu, Weijun Cai, Yangyi Qin, Lifang Wei, Heming Wang, Nan Li
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Heliyon
Subjects:
Guilu Erxian glue
Chondrocyte
Apoptosis
Knee osteoarthritis
ATF6/GRP78/CHOP signaling pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024160185

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http://www.sciencedirect.com/science/article/pii/S2405844024160185

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