miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure

miR-126-3p containing exosomes derived from human umbilical cord mesenchymal stem cells promote angiogenesis and attenuate ovarian granulosa cell apoptosis in a preclinical rat model of premature ovarian failure

Abstract Background In our previous research, we found that overexpression of miR-126-3p in human umbilical cord MSCs (hucMSCs) promoted human umbilical vein endothelial cells angiogenic activities through exosome-mediated mechanisms. The present study aimed to investigate the role of miR-126-3p-mod...

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Bibliographic Details
Main Authors: Qingxi Qu, Linghong Liu, Yuqian Cui, Hongli Liu, Jingyang Yi, Weidong Bing, Chunxiao Liu, Detian Jiang, Yanwen Bi
Format: Article
Language:English
Published: BMC 2022-07-01
Series:Stem Cell Research & Therapy
Subjects:
Exosomes
Mesenchymal stem cells
Granulosa cell
Angiogenesis
Apoptosis
Premature ovarian insufficiency
Online Access:https://doi.org/10.1186/s13287-022-03056-y

Internet

https://doi.org/10.1186/s13287-022-03056-y

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