Age and diet shape the genetic architecture of body weight in diversity outbred mice

Age and diet shape the genetic architecture of body weight in diversity outbred mice

Understanding how genetic variation shapes a complex trait relies on accurately quantifying both the additive genetic and genotype–environment interaction effects in an age-dependent manner. We used a linear mixed model to quantify diet-dependent genetic contributions to body weight measured through...

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Bibliographic Details
Main Authors: Kevin M Wright, Andrew G Deighan, Andrea Di Francesco, Adam Freund, Vladimir Jojic, Gary A Churchill, Anil Raj
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-07-01
Series:eLife
Subjects:
heritability
gene-environment interaction
diversity outbred
longitudinal
quantitative trait locus
mixed models
Online Access:https://elifesciences.org/articles/64329

Internet

https://elifesciences.org/articles/64329

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