Advances in the Structural and Physiological Functions of SHARPIN

Advances in the Structural and Physiological Functions of SHARPIN

SHARPIN was initially found as a SHANK-associated protein. SHARPIN can be used as an important component to form the linear ubiquitin chain assembly complex (LUBAC) with HOIL-1L, HOIP to produce a linear ubiquitin chain connected N-terminal Met1, playing a critical role in various cellular processes...

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Bibliographic Details
Main Authors: Beiming Yu, Feng Wang, Yanfeng Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Immunology
Subjects:
SHARPIN in LUBAC
SHARPIN alone
structure
cellular role
physiological function
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.858505/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.858505/full

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