Apolipoprotein A-I promotes cholesterol release and apolipoprotein E recruitment from THP-1 macrophage-like foam cells

Apolipoprotein A-I promotes cholesterol release and apolipoprotein E recruitment from THP-1 macrophage-like foam cells

Apolipoprotein E (apoE) is synthesized and secreted by arterial macrophages while apolipoprotein A-I (apoA-I) is present in surrounding interstitial fluids. Both apolipoproteins play important roles in macrophage cholesterol homeostasis by forming lipid complexes (nascent-HDL) with cellular phosphol...

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Bibliographic Details
Main Authors: John K. Bielicki, Mark R. McCall, Trudy M. Forte
Format: Article
Language:English
Published: Elsevier 1999-01-01
Series:Journal of Lipid Research
Subjects:
macrophage-foam cells
cholesterol recruitment
sphingomyelin
apolipoprotein A-I
apolipoprotein E
nascent-HDL assembly
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520333423

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http://www.sciencedirect.com/science/article/pii/S0022227520333423

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