Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance

Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance

The NAD-dependent deacetylase SIRT1 improves β cell function. Accordingly, nicotinamide mononucleotide (NMN), the product of the rate-limiting step in NAD synthesis, prevents β cell dysfunction and glucose intolerance in mice fed a high-fat diet. The current study was performed to assess the effects...

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Bibliographic Details
Main Authors: Ashraf Nahle, Yemisi Deborah Joseph, Sandra Pereira, Yusaku Mori, Frankie Poon, Hilda E. Ghadieh, Aleksandar Ivovic, Tejas Desai, Simona S. Ghanem, Suman Asalla, Harrison T. Muturi, Emelien M. Jentz, Jamie W. Joseph, Sonia M. Najjar, Adria Giacca
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:International Journal of Molecular Sciences
Subjects:
type 2 diabetes
insulin resistance
insulin clearance
SIRTs
glucose tolerance
free fatty acids
Online Access:https://www.mdpi.com/1422-0067/22/24/13224

Internet

https://www.mdpi.com/1422-0067/22/24/13224

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