Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance

Nicotinamide Mononucleotide Prevents Free Fatty Acid-Induced Reduction in Glucose Tolerance by Decreasing Insulin Clearance

The NAD-dependent deacetylase SIRT1 improves β cell function. Accordingly, nicotinamide mononucleotide (NMN), the product of the rate-limiting step in NAD synthesis, prevents β cell dysfunction and glucose intolerance in mice fed a high-fat diet. The current study was performed to assess the effects...

Full description

Bibliographic Details
Main Authors:	Ashraf Nahle, Yemisi Deborah Joseph, Sandra Pereira, Yusaku Mori, Frankie Poon, Hilda E. Ghadieh, Aleksandar Ivovic, Tejas Desai, Simona S. Ghanem, Suman Asalla, Harrison T. Muturi, Emelien M. Jentz, Jamie W. Joseph, Sonia M. Najjar, Adria Giacca
Format:	Article
Language:	English
Published:	MDPI AG 2021-12-01
Series:	International Journal of Molecular Sciences
Subjects:	type 2 diabetes insulin resistance insulin clearance SIRTs glucose tolerance free fatty acids
Online Access:	https://www.mdpi.com/1422-0067/22/24/13224

Similar Items

Antioxidant effect of nicotinamide mononucleotide in tendinopathy
by: Kohei Yamaura, et al.
Published: (2022-03-01)

Insulin Sensitivity Is Retained in Mice with Endothelial Loss of Carcinoembryonic Antigen Cell Adhesion Molecule 1
by: Harrison T. Muturi, et al.
Published: (2021-08-01)

Regulation of Insulin Clearance by Non-Esterified Fatty Acids
by: Sonia M. Najjar, et al.
Published: (2022-08-01)

The Role of Nicotinamide Mononucleotide Supplementation in Psoriasis Treatment
by: Zhengyi Zhang, et al.
Published: (2024-02-01)

Insulin Clearance in Obesity and Type 2 Diabetes
by: Han-Chow E. Koh, et al.
Published: (2022-01-01)

Shape of the glucose response curve during an oral glucose tolerance test is associated with insulin clearance and muscle insulin sensitivity in healthy non‐obese men
by: Hideyoshi Kaga, et al.
Published: (2020-07-01)

Hepatic CEACAM1 Overexpression Protects Against Diet-induced Fibrosis and Inflammation in White Adipose Tissue
by: Sumona Ghosh Lester, et al.
Published: (2015-08-01)

Insulin: Trigger and Target of Renal Functions
by: Ana F. Pina, et al.
Published: (2020-07-01)

Hyperinsulinemia and Its Pivotal Role in Aging, Obesity, Type 2 Diabetes, Cardiovascular Disease and Cancer
by: Joseph A. M. J. L. Janssen
Published: (2021-07-01)

Targeting Insulin-Degrading Enzyme in Insulin Clearance
by: Malcolm A. Leissring, et al.
Published: (2021-02-01)

Defining the Relative Role of Insulin Clearance in Early Dysglycemia in Relation to Insulin Sensitivity and Insulin Secretion: The Microbiome and Insulin Longitudinal Evaluation Study (MILES)
by: Alexis C. Wood, et al.
Published: (2021-06-01)

Fasting hepatic insulin clearance reflects postprandial hepatic insulin clearance: a brief report
by: Tsuyoshi Okura, et al.
Published: (2023-12-01)

The Insulin Receptor Mediates Insulin’s Early Plasma Clearance by Liver, Muscle, and Kidney
by: Rick I. Meijer, et al.
Published: (2021-01-01)

Aortic Fibrosis in Insulin-Sensitive Mice with Endothelial Cell-Specific Deletion of <i>Ceacam1</i> Gene
by: Raghd Abu Helal, et al.
Published: (2022-04-01)

β-cell function in black South African women: exploratory associations with insulin clearance, visceral and ectopic fat
by: Melony C Fortuin-de Smidt, et al.
Published: (2021-05-01)

Sleeve Gastrectomy-Induced Weight Loss Increases Insulin Clearance in Obese Mice
by: Gabriela Moreira Soares, et al.
Published: (2023-01-01)

Effects of Low-Carbohydrate versus Mediterranean Diets on Weight Loss, Glucose Metabolism, Insulin Kinetics and β-Cell Function in Morbidly Obese Individuals
by: Domenico Tricò, et al.
Published: (2021-04-01)

Resveratrol regulates insulin resistance to improve the glycolytic pathway by activating SIRT2 in PCOS granulosa cells
by: Aihong Liang, et al.
Published: (2023-01-01)

Nicotinamide Mononucleotide Supplementation Improves Mitochondrial Dysfunction and Rescues Cellular Senescence by NAD<sup>+</sup>/Sirt3 Pathway in Mesenchymal Stem Cells
by: Huan Wang, et al.
Published: (2022-11-01)

Insulin Clearance at the Pubertal Transition in Youth with Obesity and Steatosis Liver Disease
by: Roberto Franceschi, et al.
Published: (2023-10-01)

A Short-Term High-Fat Diet Worsens Insulin Sensitivity with Changes in Metabolic Parameters in Non-Obese Japanese Men
by: Satoshi Kadowaki, et al.
Published: (2023-06-01)

Short-Term SGLT2 Inhibitor Administration Does Not Alter Systemic Insulin Clearance in Type 2 Diabetes
by: Motonori Sato, et al.
Published: (2021-09-01)

Nicotinamide mononucleotide attenuates HIF-1α activation and fibrosis in hypoxic adipose tissue via NAD+/SIRT1 axis
by: Keke Wu, et al.
Published: (2023-01-01)

Amelioration of High-Insulin-Induced Skeletal Muscle Cell Insulin Resistance by Resveratrol Is Linked to Activation of AMPK and Restoration of GLUT4 Translocation
by: Filip Vlavcheski, et al.
Published: (2020-03-01)

SIRT2 Deficiency Exacerbates Hepatic Steatosis via a Putative Role of the ER Stress Pathway
by: Helena Leal, et al.
Published: (2022-06-01)

Berberine suppressed sarcopenia insulin resistance through SIRT1-mediated mitophagy
by: Su Xiaojuan, et al.
Published: (2023-07-01)

Role of Pterostilbene in Metabolic Diseases through SIRT1 pathway- A Review
by: Rashmi Patil, et al.
Published: (2021-12-01)

Nitrate consumption preserves HFD-induced skeletal muscle mitochondrial ADP sensitivity and lysine acetylation: A potential role for SIRT1
by: Henver S. Brunetta, et al.
Published: (2022-06-01)

Insulin Metabolism in Polycystic Ovary Syndrome: Secretion, Signaling, and Clearance
by: Rok Herman, et al.
Published: (2023-02-01)

Effect of intracerebroventricularly injected insulin on urinary sodium excretion by cerebroventricular streptozotocin-treated rats
by: R.F. Macedo, et al.
Published: (2003-09-01)

Effects of insulin and analogues on carcinogen-induced mammary tumours in high-fat-fed rats
by: Yusaku Mori, et al.
Published: (2018-05-01)

5-((3-Amidobenzyl)oxy)nicotinamides as SIRT2 Inhibitors: A Study of Constrained Analogs
by: Teng Ai, et al.
Published: (2023-11-01)

Nicotinamide Mononucleotide Alleviates Hyperosmolarity-Induced IL-17a Secretion and Macrophage Activation in Corneal Epithelial Cells/Macrophage Co-Culture System
by: Meng YF, et al.
Published: (2021-02-01)

Hepatocyte-Specific Co-Delivery of Zinc Ions and Plasmid DNA by Lactosylated Poly(1-vinylimidazole) for Suppression of Insulin Receptor Internalization
by: Akito Endo, et al.
Published: (2021-12-01)

Characterization of glucose metabolism in youth with vs. without cystic fibrosis liver disease: A pilot study
by: Maria Socorro Rayas, et al.
Published: (2022-06-01)

SIRT3 Modulates Endothelial Mitochondrial Redox State during Insulin Resistance
by: Elisa Martino, et al.
Published: (2022-08-01)

SGLT‐2 inhibitors enhance the effect of metformin to ameliorate hormonal changes and inflammatory markers in a rat PCOS model
by: Manal Moustafa Mahmoud, et al.
Published: (2023-11-01)

Supplementation with Red Wine Extract Increases Insulin Sensitivity and Peripheral Blood Mononuclear Sirt1 Expression in Nondiabetic Humans
by: Munehiro Kitada, et al.
Published: (2020-10-01)

Evaluation of potential gene expression as early markers of insulin resistance and non-alcoholic fatty liver disease in the Indonesian population
by: Eunice Limantara, et al.
Published: (2018-12-01)

Adipose Tissue SIRT1 Regulates Insulin Sensitizing and Anti-Inflammatory Effects of Berberine
by: Yun Shan, et al.
Published: (2020-12-01)