Cheminformatics-Guided Exploration of Synthetic Marine Natural Product-Inspired Brominated Indole-3-Glyoxylamides and Their Potentials for Drug Discovery

Cheminformatics-Guided Exploration of Synthetic Marine Natural Product-Inspired Brominated Indole-3-Glyoxylamides and Their Potentials for Drug Discovery

Marine natural products (MNPs) continue to be tested primarily in cellular toxicity assays, both mammalian and microbial, despite most being inactive at concentrations relevant to drug discovery. These MNPs become missed opportunities and represent a wasteful use of precious bioresources. The use of...

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Bibliographic Details
Main Authors: Darren C. Holland, Dale W. Prebble, Mark J. Calcott, Wayne A. Schroder, Francesca Ferretti, Aaron Lock, Vicky M. Avery, Milton J. Kiefel, Anthony R. Carroll
Format: Article
Language:English
Published: MDPI AG 2024-08-01
Series:Molecules
Subjects:
indole synthesis
indol-3-yl-glyoxylamides
marine indole alkaloids
marine natural products
cheminformatics
Parkinson’s disease
Online Access:https://www.mdpi.com/1420-3049/29/15/3648

Internet

https://www.mdpi.com/1420-3049/29/15/3648

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