Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe.

Using canavanine resistance to measure mutation rates in Schizosaccharomyces pombe.

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We constructed a panel of S. pombe strains expressing DNA polymerase ε variants associated with cancer, specifically POLES297F, POLEV411L, POLEL424V, POLES459F, and used these to compare mutation rates determined by canavanine resistance with other selective methods. Canavanine-resistance mutation r...

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Bibliographic Details
Main Authors: Chen-Chun Pai, Ellen Heitzer, Sibyl Bertrand, Sophia Toumazou, Timothy C Humphrey, Stephen E Kearsey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0271016

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https://doi.org/10.1371/journal.pone.0271016

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