Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice

Essential Involvement of Neutrophil Elastase in Acute Acetaminophen Hepatotoxicity Using BALB/c Mice

Intense neutrophil infiltration into the liver is a characteristic of acetaminophen-induced acute liver injury. Neutrophil elastase is released by neutrophils during inflammation. To elucidate the involvement of neutrophil elastase in acetaminophen-induced liver injury, we investigated the efficacy...

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Bibliographic Details
Main Authors: Yuko Ishida, Siying Zhang, Yumi Kuninaka, Akiko Ishigami, Mizuho Nosaka, Isui Harie, Akihiko Kimura, Naofumi Mukaida, Toshikazu Kondo
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:International Journal of Molecular Sciences
Subjects:
drug-induced hepatotoxicity
acetaminophen
neutrophils
neutrophil elastase
sivelestat
inflammation
Online Access:https://www.mdpi.com/1422-0067/24/9/7845

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https://www.mdpi.com/1422-0067/24/9/7845

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