Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells

Canonical WNT pathway inhibition reduces ATP synthesis rates in glioblastoma stem cells

Background: The conserved stem cell signaling network canonical Wingless (WNT) plays important roles in development and disease. Aberrant activation of this pathway has been linked to tumor progression and resistance to therapy. Industry and academia have substantially invested in developing substan...

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Bibliographic Details
Main Authors: Dymphna Margriet Ouwens, Michael Hewera, Guanzhang Li, Wang Di, Sajjad Muhammad, Daniel Hänggi, Hans-Jakob Steiger, Claudia A. Dumitru, Erol Sandalcioglu, Roland S Croner, Wei Zhang, Or Kakhlon, Ulf D. Kahlert
Format: Article
Language:English
Published: IMR Press 2022-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
tumor stem cells
wnt
metabolism
bioenergetics
single cell rna sequencing
Online Access:https://www.imrpress.com/journal/FBL/27/1/10.31083/j.fbl2701035

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https://www.imrpress.com/journal/FBL/27/1/10.31083/j.fbl2701035

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