Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R

Functional and Pharmacological Characterization of the Rare CFTR Mutation W361R

Understanding the functional consequence of rare cystic fibrosis (CF) mutations is mandatory for the adoption of precision therapeutic approaches for CF. Here we studied the effect of the very rare CF mutation, W361R, on CFTR processing and function. We applied western blot, patch clamp and pharmaco...

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Bibliographic Details
Main Authors: Arnaud Billet, Ahmad Elbahnsi, Mathilde Jollivet-Souchet, Brice Hoffmann, Jean-Paul Mornon, Isabelle Callebaut, Frédéric Becq
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Pharmacology
Subjects:
W361R-CFTR
missense CF mutations
class-2 CF mutations
small molecules modulators
cystic fibrosis transmembrane conductance regulator
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00295/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2020.00295/full

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