PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression

PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression

Cancer associated fibroblasts are an important and highly heterogeneous component of the tumor microenvironment. Here the authors identify PRRX1 as a master transcription factor determining a fibroblast lineage with myofibroblastic phenotype, associated with unfavourable prognosis in several cancer...

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Bibliographic Details
Main Authors: Keun-Woo Lee, So-Young Yeo, Jeong-Ryeol Gong, Ok-Jae Koo, Insuk Sohn, Woo Yong Lee, Hee Cheol Kim, Seong Hyeon Yun, Yong Beom Cho, Mi-Ae Choi, Sugyun An, Juhee Kim, Chang Ohk Sung, Kwang-Hyun Cho, Seok-Hyung Kim
Format: Article
Language:English
Published: Nature Portfolio 2022-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30484-4

Internet

https://doi.org/10.1038/s41467-022-30484-4

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