PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression
Cancer associated fibroblasts are an important and highly heterogeneous component of the tumor microenvironment. Here the authors identify PRRX1 as a master transcription factor determining a fibroblast lineage with myofibroblastic phenotype, associated with unfavourable prognosis in several cancer...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-30484-4 |
| _version_ | 1811250945812594688 |
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| author | Keun-Woo Lee So-Young Yeo Jeong-Ryeol Gong Ok-Jae Koo Insuk Sohn Woo Yong Lee Hee Cheol Kim Seong Hyeon Yun Yong Beom Cho Mi-Ae Choi Sugyun An Juhee Kim Chang Ohk Sung Kwang-Hyun Cho Seok-Hyung Kim |
| author_facet | Keun-Woo Lee So-Young Yeo Jeong-Ryeol Gong Ok-Jae Koo Insuk Sohn Woo Yong Lee Hee Cheol Kim Seong Hyeon Yun Yong Beom Cho Mi-Ae Choi Sugyun An Juhee Kim Chang Ohk Sung Kwang-Hyun Cho Seok-Hyung Kim |
| author_sort | Keun-Woo Lee |
| collection | DOAJ |
| description | Cancer associated fibroblasts are an important and highly heterogeneous component of the tumor microenvironment. Here the authors identify PRRX1 as a master transcription factor determining a fibroblast lineage with myofibroblastic phenotype, associated with unfavourable prognosis in several cancer types. |
| first_indexed | 2024-04-12T16:12:20Z |
| format | Article |
| id | doaj.art-f8a3db8d4f924585bc63f79a50a42110 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T16:12:20Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f8a3db8d4f924585bc63f79a50a421102022-12-22T03:25:52ZengNature PortfolioNature Communications2041-17232022-05-0113112310.1038/s41467-022-30484-4PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progressionKeun-Woo Lee0So-Young Yeo1Jeong-Ryeol Gong2Ok-Jae Koo3Insuk Sohn4Woo Yong Lee5Hee Cheol Kim6Seong Hyeon Yun7Yong Beom Cho8Mi-Ae Choi9Sugyun An10Juhee Kim11Chang Ohk Sung12Kwang-Hyun Cho13Seok-Hyung Kim14Department of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityDepartment of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and TechnologyToolGen Inc., Gasan digital 1-ro, GeumcheonArontier Inc., Gangnam-daeroDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Surgery, Samsung Medical Center, Sungkyunkwan University School of MedicineDepartment of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Pathology, Asan Medical Center, University of Ulsan College of MedicineDepartment of Bio and Brain Engineering, Korea Advanced Institute of Science and TechnologyDepartment of Health Science and Technology, Samsung Advanced Institute for Health Science and Technology, Sungkyunkwan UniversityCancer associated fibroblasts are an important and highly heterogeneous component of the tumor microenvironment. Here the authors identify PRRX1 as a master transcription factor determining a fibroblast lineage with myofibroblastic phenotype, associated with unfavourable prognosis in several cancer types.https://doi.org/10.1038/s41467-022-30484-4 |
| spellingShingle | Keun-Woo Lee So-Young Yeo Jeong-Ryeol Gong Ok-Jae Koo Insuk Sohn Woo Yong Lee Hee Cheol Kim Seong Hyeon Yun Yong Beom Cho Mi-Ae Choi Sugyun An Juhee Kim Chang Ohk Sung Kwang-Hyun Cho Seok-Hyung Kim PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression Nature Communications |
| title | PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression |
| title_full | PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression |
| title_fullStr | PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression |
| title_full_unstemmed | PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression |
| title_short | PRRX1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression |
| title_sort | prrx1 is a master transcription factor of stromal fibroblasts for myofibroblastic lineage progression |
| url | https://doi.org/10.1038/s41467-022-30484-4 |
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