Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP

Cell Division Protein FtsZ Is Unfolded for N-Terminal Degradation by Antibiotic-Activated ClpP

ABSTRACT Antibiotic acyldepsipeptides (ADEPs) deregulate ClpP, the proteolytic core of the bacterial Clp protease, thereby inhibiting its native functions and concomitantly activating it for uncontrolled proteolysis of nonnative substrates. Importantly, although ADEP-activated ClpP is assumed to tar...

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Bibliographic Details
Main Authors: Nadine Silber, Stefan Pan, Sina Schäkermann, Christian Mayer, Heike Brötz-Oesterhelt, Peter Sass
Format: Article
Language:English
Published: American Society for Microbiology 2020-06-01
Series:mBio
Subjects:
ADEP
antibiotics
acyldepsipeptides
guanosine nucleotides
protein unfolding
cytokinesis
Online Access:https://journals.asm.org/doi/10.1128/mBio.01006-20

Internet

https://journals.asm.org/doi/10.1128/mBio.01006-20

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