Case report of pediatric TTMV-related acute promyelocytic leukemia with central nervous system infiltration and rapid accumulation of RARA-LBD mutations

Case report of pediatric TTMV-related acute promyelocytic leukemia with central nervous system infiltration and rapid accumulation of RARA-LBD mutations

TTMV::RARA is a recently reported fusion gene associated with acute promyelocytic leukemia (APL), caused by the integration of torque teno mini virus (TTMV) genomic fragments into the second intron of the RARA gene. Currently, there have been only six documented cases, with clinical presentations sh...

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Bibliographic Details
Main Authors: Linya Wang, Jiaqi Chen, Bei Hou, Ying Wu, Jun Yang, Xiaosu Zhou, Qihui Chen, Xue Chen, Yang Zhang, Fang Wang, Jiancheng Fang, Panxiang Cao, Mingyue Liu, Yanan Li, Pan Zhang, Yan Liu, Ruidong Zhang, Hongxing Liu, Huyong Zheng
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Heliyon
Subjects:
Acute promyelocytic leukemia (APL)
Torque teno mini virus (TTMV)
Whole transcriptome sequencing (WTS)
TTMV::RARA
Case report
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844024031384

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