The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis

The Protective Effects of IL-31RA Deficiency During Bleomycin-Induced Pulmonary Fibrosis

Idiopathic Pulmonary Fibrosis (IPF) is a severe fibrotic lung disease characterized by excessive collagen deposition and progressive decline in lung function. Th2 T cell-derived cytokines including IL-4 and IL-13 have been shown to contribute to inflammation and fibrotic remodeling in multiple tissu...

Full description

Bibliographic Details
Main Authors:	Dan J. K. Yombo, Varshini Odayar, Nishant Gupta, Anil G. Jegga, Satish K. Madala
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-03-01
Series:	Frontiers in Immunology
Subjects:	interleukin 31 interleukin 31 receptor alpha lung idiopathic pulmonary fibrosis bleomycin IL-31 regulation of pulmonary fibrosis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2021.645717/full

Similar Items

Blockage of the IL-31 Pathway as a Potential Target Therapy for Atopic Dermatitis
by: Raquel Leao Orfali, et al.
Published: (2023-02-01)

Analyzing the Antinociceptive Effect of Interleukin-31 in Mice
by: Iwao Arai, et al.
Published: (2023-07-01)

Interleukin-31, Interleukin-31RA, and OSMR Expression Levels in Post-burn Hypertrophic Scars
by: Mi Young Lee, et al.
Published: (2018-09-01)

Experimental Study: Interleukin-31 Augments Morphine-Induced Antinociceptive Activity and Suppress Tolerance Development in Mice
by: Iwao Arai, et al.
Published: (2023-11-01)

Dysregulation of Mesenchymal Cell Survival Pathways in Severe Fibrotic Lung Disease: The Effect of Nintedanib Therapy
by: Rajesh K. Kasam, et al.
Published: (2019-05-01)

Interleukin-31 new biomarker of infectious skin diseases
by: Diana Dorosh
Published: (2021-07-01)

Interleukin-31 in serum and cerebrospinal fluid of dogs with syringomyelia
by: Laura Lemke, et al.
Published: (2023-11-01)

Immune Mechanisms of Pulmonary Fibrosis with Bleomycin
by: Yuko Ishida, et al.
Published: (2023-02-01)

Wilms Tumor 1-Driven Fibroblast Activation and Subpleural Thickening in Idiopathic Pulmonary Fibrosis
by: Prathibha R. Gajjala, et al.
Published: (2023-02-01)

Plumbagin attenuates Bleomycin-induced lung fibrosis in mice
by: Saber Mehdizadeh, et al.
Published: (2022-10-01)

Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice
by: Iwao Arai, et al.
Published: (2022-01-01)

Interleukin-31 Receptor A Expression in the Dorsal Root Ganglion of Mice with Atopic Dermatitis
by: Iwao Arai, et al.
Published: (2023-01-01)

Possible Role of Interleukin-31/33 Axis in Imatinib Mesylate-Associated Skin Toxicity
by: Caterina Musolino, et al.
Published: (2015-05-01)

Possible Association of Interleukin-31/-31RA Signalling and Basophils with Itch in Porokeratosis
by: Satoshi Okuno, et al.
Published: (2023-10-01)

Oncostatin M suppresses IL31RA expression in dorsal root ganglia and interleukin-31-induced itching
by: Masataka Suehiro, et al.
Published: (2023-11-01)

Interrelationship and Sequencing of Interleukins4, 13, 31, and 33 – An Integrated Systematic Review: Dermatological and Multidisciplinary Perspectives
by: Tatu AL, et al.
Published: (2022-09-01)

Consensus Gene Co-Expression Network Analysis Identifies Novel Genes Associated with Severity of Fibrotic Lung Disease
by: Sudhir Ghandikota, et al.
Published: (2022-05-01)

IL-31 and IL-33 in rheumatoid arthritis patients
by: N. A. Lapkina, et al.
Published: (2022-11-01)

The Effect of Methanol Extract of Fennel on Bleomycin-Induced Pulmonary Fibrosis in Rats
by: Mitra Samareh-Fekri, et al.
Published: (2015-12-01)

Unsupervised gene expression analyses identify IPF-severity correlated signatures, associated genes and biomarkers
by: Yunguan Wang, et al.
Published: (2017-10-01)

Profile of Serum Interleukin-31 Levels in Atopic Dermatitis
by: Dewi Kusumawati, et al.
Published: (2017-08-01)

IL-22 inhibits bleomycin-induced pulmonary fibrosis in association with inhibition of IL-17A in mice
by: Ziye Qu, et al.
Published: (2022-12-01)

Pulmonary cytotoxicity induced by bleomycin and methotrexate
by: Zh, V, Sheykh, et al.
Published: (2016-03-01)

Efficacy and safety of vixarelimab, a human monoclonal oncostatin M receptor β antibody, in moderate-to-severe prurigo nodularis: a randomised, double-blind, placebo-controlled, phase 2a studyResearch in context
by: Howard Sofen, et al.
Published: (2023-03-01)

A case of bleomycin-induced lung toxicity
by: Cuneyt Tetikkurt, et al.
Published: (2018-11-01)

Design and Production of a Novel Recombinant Chimeric IL2-Omp31 Antigen against Brucella Infection
by: M. Naghavi, et al.
Published: (2018-09-01)

Atractylodin ameliorates bleomycin-induced pulmonary inflammation and fibrosis in mice
by: Zhenhui Wu, et al.
Published: (2023-09-01)

Macrophage‐based delivery of anti‐fibrotic proteins alleviates bleomycin‐induced pulmonary fibrosis in mice
by: Huiying Liu, et al.
Published: (2023-09-01)

Association of Periodontitis and Atopic Dermatitis with the Levels of IL-13, IL-31, and TSLP in the Gingival Crevicular Fluid
by: Constanza Jiménez, et al.
Published: (2023-10-01)

Evaluation of the role of interleukin-31 in inflammatory acne vulgaris: a case–control study
by: Shahira A Ramadan, et al.
Published: (2020-01-01)

Resistin-like molecule alpha1 (Fizz1) recruits lung dendritic cells without causing pulmonary fibrosis
by: Madala Satish K, et al.
Published: (2012-06-01)

Establishment of an Intradermal Canine IL-31-Induced Pruritus Model to Evaluate Therapeutic Candidates in Atopic Dermatitis
by: Jason Pearson, et al.
Published: (2023-05-01)

Nintedanib Inhibits Endothelial Mesenchymal Transition in Bleomycin-Induced Pulmonary Fibrosis via Focal Adhesion Kinase Activity Reduction
by: Wen-Kuang Yu, et al.
Published: (2022-07-01)

Production of IL-31 in CD45RO<sup>+</sup>CLA<sup>+</sup>H4R<sup>+</sup> T Cells in Atopic Dermatitis
by: Chul Hwan Bang, et al.
Published: (2021-05-01)

The Anti-Fibrotic Effects of CG-745, an HDAC Inhibitor, in Bleomycin and PHMG-Induced Mouse Models
by: Young-Suk Kim, et al.
Published: (2019-07-01)

Dynamic Observation of Autophagy and Transcriptome Profiles in a Mouse Model of Bleomycin-Induced Pulmonary Fibrosis
by: Yani Wang, et al.
Published: (2021-07-01)

Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis
by: Shun Takao, et al.
Published: (2021-09-01)

Bleomycin induced urethral stricture in Hodgkin′s disease
by: Ritesh Tapkire, et al.
Published: (2009-01-01)

Protective Effects of Hydroalcoholic Extract of Hypericum Perforatum Against Bleomycin-Induced Pulmonary Fibrosis in Rats
by: E Ebrahimi Naghani, et al.
Published: (2016-01-01)

Combination of losartan with pirfenidone: a protective anti-fibrotic against pulmonary fibrosis induced by bleomycin in rats
by: Arian Amirkhosravi, et al.
Published: (2024-04-01)