Treatment Resistance in Severe Asthma Patients With a Combination of High Fraction of Exhaled Nitric Oxide and Low Blood Eosinophil Counts

Treatment Resistance in Severe Asthma Patients With a Combination of High Fraction of Exhaled Nitric Oxide and Low Blood Eosinophil Counts

Background: Combining a fraction of exhaled nitric oxide (FeNO) and blood eosinophil count (B-EOS) may be a useful strategy for administration of biologics such as anti-IgE or anti-IL-5 to patients with type 2 inflammatory-predominant severe asthma and is important to be elucidated considering the i...

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Bibliographic Details
Main Authors: Yuki Hoshino, Tomoyuki Soma, Yoshitaka Uchida, Yuki Shiko, Kazuyuki Nakagome, Makoto Nagata
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-04-01
Series:Frontiers in Pharmacology
Subjects:
blood eosinophil count
fraction of exhaled nitric oxide (feno)
sputum eosinophilia
sputum neutrophil-predominant
asthma exacerbation (AE)
anti-IL-5 biologics
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.836635/full

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https://www.frontiersin.org/articles/10.3389/fphar.2022.836635/full

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