Retromer disruption promotes amyloidogenic APP processing

Retromer disruption promotes amyloidogenic APP processing

Retromer deficiency has been implicated in sporadic AD and animals deficient in retromer components exhibit pronounced neurodegeneration. Because retromer performs retrograde transport from the endosome to the Golgi apparatus and neuronal Aβ is found in late endosomal compartments, we speculated tha...

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Bibliographic Details
Main Authors: Christopher P. Sullivan, Anthony G. Jay, Edward C. Stack, Maria Pakaluk, Erin Wadlinger, Richard E. Fine, John M. Wells, Peter J. Morin
Format: Article
Language:English
Published: Elsevier 2011-08-01
Series:Neurobiology of Disease
Subjects:
Retromer
Vps35
APP
Aβ
Exosome
Endosome
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111001197

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http://www.sciencedirect.com/science/article/pii/S0969996111001197

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