TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

The emergence of multi-drug-resistant Gram-negative pathogens highlights an urgent clinical need to explore and develop new antibiotics with novel antibacterial targets. MreB is a promising antibacterial target that functions as an essential elongasome protein in most Gram-negative bacterial rods. H...

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Bibliographic Details
Main Authors: Eric J. Bryan, Hye Yeon Sagong, Ajit K. Parhi, Mark C. Grier, Jacques Y. Roberge, Edmond J. LaVoie, Daniel S. Pilch
Format: Article
Language:English
Published: MDPI AG 2022-05-01
Series:Antibiotics
Subjects:
bactericidal efficacy
<i>Escherichia coli</i>
<i>Klebsiella pneumoniae</i>
<i>Acinetobacter baumannii</i>
<i>Pseudomonas aeruginosa</i>
noncompetitive inhibition of MreB ATPase activity
Online Access:https://www.mdpi.com/2079-6382/11/5/693

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https://www.mdpi.com/2079-6382/11/5/693

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