TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

TXH11106: A Third-Generation MreB Inhibitor with Enhanced Activity against a Broad Range of Gram-Negative Bacterial Pathogens

The emergence of multi-drug-resistant Gram-negative pathogens highlights an urgent clinical need to explore and develop new antibiotics with novel antibacterial targets. MreB is a promising antibacterial target that functions as an essential elongasome protein in most Gram-negative bacterial rods. H...

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Bibliographic Details
Main Authors:	Eric J. Bryan, Hye Yeon Sagong, Ajit K. Parhi, Mark C. Grier, Jacques Y. Roberge, Edmond J. LaVoie, Daniel S. Pilch
Format:	Article
Language:	English
Published:	MDPI AG 2022-05-01
Series:	Antibiotics
Subjects:	bactericidal efficacy <i>Escherichia coli</i> <i>Klebsiella pneumoniae</i> <i>Acinetobacter baumannii</i> <i>Pseudomonas aeruginosa</i> noncompetitive inhibition of MreB ATPase activity
Online Access:	https://www.mdpi.com/2079-6382/11/5/693

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