Studying Conformational Properties of Transmembrane Domain of KCNE3 in a Lipid Bilayer Membrane Using Molecular Dynamics Simulations

Studying Conformational Properties of Transmembrane Domain of KCNE3 in a Lipid Bilayer Membrane Using Molecular Dynamics Simulations

KCNE3 is a single-pass integral membrane protein that regulates numerous voltage-gated potassium channel functions such as KCNQ1. Previous solution NMR studies suggested a moderate degree of curved α-helical structure in the transmembrane domain (TMD) of KCNE3 in lyso-myristoylphosphatidylcholine (L...

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Bibliographic Details
Main Authors: Anna Clara Miranda Moura, Isaac K. Asare, Mateo Fernandez Cruz, Antonio Javier Franco Aguado, Kaeleigh Dyan Tuck, Conner C. Campbell, Matthew W. Scheyer, Ikponwmosa Obaseki, Steve Alston, Andrea N. Kravats, Charles R. Sanders, Gary A. Lorigan, Indra D. Sahu
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Membranes
Subjects:
molecular dynamics simulation
KCNE3 transmembrane domain
conformational dynamics
lipid bilayers
Online Access:https://www.mdpi.com/2077-0375/14/2/45

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https://www.mdpi.com/2077-0375/14/2/45

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