Fibroblast Growth Factor 21 Modulates Microglial Polarization That Attenuates Neurodegeneration in Mice and Cellular Models of Parkinson's Disease

Fibroblast Growth Factor 21 Modulates Microglial Polarization That Attenuates Neurodegeneration in Mice and Cellular Models of Parkinson's Disease

Microglial polarization and the subsequent neuroinflammatory response were identified as key contributors to the progress of Parkinson's disease (PD). Researchers have shown that fibroblast growth factor 21 (FGF21) plays multiple biological functions, including anti-inflammation and neuroprotec...

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Bibliographic Details
Main Authors: Changwei Yang, Wuqiong Wang, Pengxi Deng, Chen Li, Liangcai Zhao, Hongchang Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-12-01
Series:Frontiers in Aging Neuroscience
Subjects:
dopaminergic neurodegeneration
fibroblast growth factor
microglia phenotype
neuroinflammation
sirtuin 1
cognitive decline
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2021.778527/full

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https://www.frontiersin.org/articles/10.3389/fnagi.2021.778527/full

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