Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

Retro-2 protects cells from ricin toxicity by inhibiting ASNA1-mediated ER targeting and insertion of tail-anchored proteins

The small molecule Retro-2 prevents ricin toxicity through a poorly-defined mechanism of action (MOA), which involves halting retrograde vesicle transport to the endoplasmic reticulum (ER). CRISPRi genetic interaction analysis revealed Retro-2 activity resembles disruption of the transmembrane domai...

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Bibliographic Details
Main Authors: David W Morgens, Charlene Chan, Andrew J Kane, Nicholas R Weir, Amy Li, Michael M Dubreuil, C Kimberly Tsui, Gaelen T Hess, Adam Lavertu, Kyuho Han, Nicole Polyakov, Jing Zhou, Emma L Handy, Philip Alabi, Amanda Dombroski, David Yao, Russ B Altman, Jason K Sello, Vladimir Denic, Michael C Bassik
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
CRISPR
Retro-2
TRC pathway
Online Access:https://elifesciences.org/articles/48434

Internet

https://elifesciences.org/articles/48434

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